Aprepitant

Mechanism of Action 1

  • Aprepitant is a neurokinin-1 (NK1) receptor antagonist. NK receptors in the brain are involved in nausea.

Pharmacology 1

  • Half-life: Approximately 40 hours

    Indications 1

  • Very effective in reducing the incidence of Post-operative Nausea and VomitingPost-operative Nausea and Vomiting
    General Principles

    Many patients undergoing anesthesia will experience post-operative nausea and vomiting
    Anti-emetic medications are given routinely during anesthesia.
    Combining agents of d...

    Dosage 1

  • 40 mg or 80 mg (only 80 mg formulation is available in Calgary)

Complications 2

  • In patients receiving hormonal contraceptive therapy, alternative contraception should be used for 1 month following administration.

  • References

  1. Tong J. Gan, Kumar G. Belani, Sergio Bergese, Frances Chung, Pierre Diemunsch, Ashraf S. Habib, Zhaosheng Jin, Anthony L. Kovac, Tricia A. Meyer, Richard D. Urman, Christian C. Apfel, Sabry Ayad, Linda Beagley, Keith Candiotti, Marina Englesakis, Traci L. Hedrick, Peter Kranke, Samuel Lee, Daniel Lipman, Harold S. Minkowitz, John Morton, Beverly K. Philip. Fourth Consensus Guidelines for the Management of Postoperative Nausea and Vomiting, 2020. ↩ ↩2 ↩3 ↩4

  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021549s015lbl.pdf ↩