Ketorolac

What is Ketorolac?

• Nonsteroidal anti-inflammatory drug used primarily for short term, acute pain management.

Mechanism of Action ¹

• COX-1 and COX-2 inhibitor
  • COX-1: involved in platelet aggregation, gastric mucosa, vascular endothelium
  • COX-2: converts arachadonic acid -> prostaglandins -> inflammation. Inhibition provides analgesic and anti-inflmmatory properties.
• Rapidly absorbed after oral administration. Binds to plasma proteins and is metabolized in the liver. Metabolites excreted mainly by the kidney.
• Half-life: 5-6 hours.

Dosage

• 15 - 30 mg PO/IV every 6 hours. Ceiling effect exists above 15 mg.
• Pediatrics 0.5 mg/kg PO/IV every 6 hours

Indications

• Analgesia (see Pain Management

  Pain Management Private or Broken Links The page you're looking for is either not available or private! )

Contraindications [^3]

• Renal insufficiency
• Pregnancy (risks premature ductus arteriosus)
• Bleeding disorders
• Surgical concerns of bone, wound or anastomosis
• peptic ulcer

References